Disseminated Fusarium infection presenting as bilateral endogenous endophthalmitis in a patient with acute myeloid leukemia.

onstrated no signs of infection and laboratory studies did not reveal a source of infection. Scattered cerebral infarction from arterial air emboli was unlikely because no evidence of ischemia was detected on a diffusion-weighted MRI. The timing of cortical blindness in our patient, shortly after inadvertent arterial entry during attempted PICC line placement, and the focal leptomeningeal enhancement on MRI suggest that breakdown of the bloodbrain barrier was iatrogenic. The precise mechanisms underlying this process remain unclear, but we postulate that transient hyperosmolarity and hypertension may have been involved in the pathogenesis of our patient’s symptoms.